Endocrine Abstracts

Objective: Serum thyroglobulin doubling time (Tg-DT/DR) is a valuable marker for predicting recurrences/metastases and response to treatment in patients with well-differentiated follicular cell-derived thyroid carcinoma. Similarly, tumor-volume doubling time/rate (TV-DT/DR) is helpful in predicting tumor progression during active surveillance of papillary microcarcinoma and chemotherapy. However, no study has investigated the clinical significance of Tg-DT/DR and TV-DT/DR in p...

Aim: Re-analyzing the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-method: i) Patients: at onset 175 men with hypogonadism (median age: 64 years). ii) Distribution: by decade. iii) TUD (Nebido-Bayer-Schering) 1000 mg was injected one per 3 months i.m. iv) Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5 MHz probe, elliptical volume (cm3), Aloka 550. v) Time of analysis: before start...

Introduction: Our aim is to investigate whether ovarian reserve is decreased in patients with euthyroid Hashimoto’s thyroiditis (HT).Method: Our study included 110 euthyroid HT patients and 72 age matched healthy women (controls; C). In all patients FSH, LH E2, and P levels were measured from blood samples, and ovarian volumes (OV) and antral follicule count (AFC) were measured using ultrasonography at 3rd day of menstruation....

Background: Reduced growth hormone (GH) secretory capacity is common in patients with obesity and metabolic derangements. The prevalence of GH deficiency (GHD) in this population is difficult to establish. Magnetic Resonance Imaging (MRI) pituitary findings may reflect specific endocrine alterations, as for GHD which is associated with lower pituitary height and volume (PV).Purpose: Our aim was to identify the pituitary morphological alterations predicti...

Aim: Re-analysing the effect of injectable testosterone undecanoate depot (TUD) in hypogonadic patients.Materials and method: (A) Patients: at onset 210 men with hypogonadism (median age: 61.5 years). (B) Distribution: by decade; n=4, 12, 21, 54, 59, 43, 16, and 1. (C) TUD (NebidoR-Bayer-Schering) 1000 mg was injected one per 3 months i.m. (D) Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5 MHz probe, elliptical volume (cm...

Objective: To evaluate the relation of mean platelet volume (MPV) levels with serum paraoxonase-1 activity and brachial artery diameter and intima media thickness in diabetic patients with respect to obesity and diabetic complications.Methods: A total of 201 diabetic patients grouped with respect to obesity (obese (n=89) and non-obese (n=112) and diabetic complications (with (n=50) or without (n=150) microvascular comp...

Introduction and objective: Cardiovascular mortality is high in acromegaly. Our aim in this study was to determine the levels of the new cardiovascular marker in active acromegaly patients, the mean platelet volume (MPV) values before and after octreotide acetate LAR treatment.Material and methods: Thirty-six patients with active acromegaly who presented at the endocrinology department (mean age 46.0±14.0 years and mean BMI: 30.4±5.1 kg/m2...

Introduction: Although some studies have shown elevated soluble interleukin 2 receptor (sIL-2R) in sera of patients with hematological malignancies and some autoimmune diseases, its role in serum is not fully understood.Patients and methods: The aim was to compare serum levels of sIL-2R in four groups of women (11 with Graves’ disease, 10 with Hashimoto’s thyroiditis, 11 with breast cancer and 10 healthy controls) and to test their possible rel...

Background: Pheochromocytoma/Paraganglioma (PPGL) are rare neuroendocrine tumors that expresses somatostatin receptors (SSTR) and can be treated with radiolabeled somatostatin analogues such as Lu-177-DOTATATE. Ga-68-DOTATATE PET scans show the distribution and density of SSTR+ tumors, and F-18-FDG PET scans show hypermetabolism in lesions. Total uptake volumes (TUV) for each respective scan can be obtained consistently and semi-automatically using standardized workflow in ima...

Objective: Our institution (University Hospital “L. Vanvitelli“ - Naples, Italy) is a high-volume (HV) center in Naples metropolitan area and many patients are referred there to repeat thyroid fine-needle aspiration cytology (FNAC) after initial FNAC performed in low-volume institutions (LV). The aims of the study were to 1) to examine the inter-observer agreement between HV and LV institutions according to the Italian thyroid cytology system, and 2) explore how the ...